Serena Williams is opening up about her experience with GLP-1 medications. The 43-year-old tennis star has lost 31 pounds on the drug Zepbound, a type of medication typically prescribed for diabetes and now also used for weight management.
Williams’ struggles with body image began with postpartum changes after she gave birth to her first daughter, Alexis Olympia, in 2017, and continued after her second daughter, Adira River, was born in August 2023. She lost “a lot” of weight in the two weeks after River’s birth, she told People, but afterwards, “never lost another pound.”
The tennis star’s candor may help to dispel the pesky health inaccuracy that weight loss is a simple matter of exercise. While an active life and healthy eating can help with the process, new research suggests that outside factors like genetics may play a bigger role than previously thought. As arguably one of the world’s greatest athletes, Williams’ decision to share her journey with GLP-1s may help to reshape the image of the drugs.
‘A misconception is that it’s a shortcut,’ she said in the interview. ‘As an athlete and as someone that has done everything, I just couldn’t get my weight to where I needed to be at a healthy place − and believe me, I don’t take shortcuts.’
Female stars struggle under the spotlight
In a 2018 interview with Teen Vogue, Williams shared details of the body shaming she’d experienced throughout her career: “People would say I was born a guy, all because of my arms, or because I’m strong. I was different to Venus: she was thin and tall and beautiful, and I am strong and muscular − and beautiful, but, you know, it was just totally different.”
In March 2025, Meghan Trainor also opened up about struggles with body image postpartum. The Grammy winner, 31, told USA TODAY she had been looking forward to getting breast implants since she was a teenager, but pregnancy and two C-sections intensified the desire.
“It was tough to look at my body,” she said at the time. “I’m always singing about loving myself, and it got harder and harder with all the scars and stretch marks. And then after losing weight, too, these boobs were just purely empty, just flat and just felt like skin on my body.”
Likewise, rugby champion Ilona Maher has used her platform to become a revolutionary body-positive activist and an inspiration for younger generations of women and athletes.
Williams says it’s important to teach people to be confident at any size, like she tries to be.
“The size I was before, there was nothing wrong with it. It’s just not what I wanted to have,” she clarified. “I just knew that I wanted to be where I personally felt comfortable.”
“Weight loss should never really change your self image,” she said. “Women often experience judgment about their bodies at any size, and I’m no stranger to that. So I feel like you should love yourself at any size and any look.”
While the rise of GLP-1s brings a myriad of valid concerns − such as its contribution to disordered eating and promotion of thinness as the ideal body type − Williams’ outspokenness is a crucial, balanced example of healthy and transparent GLP-1 usage.
Celebrities should be transparent about their weight loss
We’re not just in a period of rapid, GLP-1 induced weight loss, we’ve also entered the “undetectable era” of plastic surgery. Cosmetic procedures and filler are no longer obvious on celebrities’ faces, rather more celebrities simply look like they haven’t aged.
Mental health experts agree that celebrities sharing what work they’ve had done, or how they’ve gone about transformative weight loss journeys, can help fans maintain healthy, realistic beauty standards. The undetectable era may bring less transparency − making it more crucial than ever for people to stop comparing their looks to celebrities’.
‘It may establish an unattainable ideal, and I think that the more we get comfortable with who we are, the less that becomes an issue,’ psychotherapist Stephanie Sarkis previously told USA TODAY. ‘We tend to not compare ourselves with others when we are feeling OK about ourselves.’
Williams wants to have an ‘honest conversation’ about GLP-1s
While the drugs, which have skyrocketed in popularity and ripped through Hollywood, offered Williams the extra boost she needed, she told Vogue she was aware of how much of a stigma remained.
‘I’m not saying any of this lightly, which is why it’s so important to have an honest conversation about this topic,’ she said. ‘I’m the mom of two girls, and I wanted to be very honest about what I’m doing so they can always be the same with me and we can have an open relationship.’
The medications, which work by targeting certain hormones to suppress appetite, have made Williams feel ‘sexier’ and ‘more confident,’ she said. And as for those who say if you work hard enough in the gym, you won’t need the drugs, Williams says they’re misinformed.
‘Sometimes you need help. Your story is your story, and it’s okay to make that choice to do it if you want to,’ she told Vogue. ‘I did, and I’m really happy with it.’